I think df.replace()
does the job, since pandas 0.13:
df = pd.DataFrame([
[-0.532681, 'foo', 0],
[1.490752, 'bar', 1],
[-1.387326, 'foo', 2],
[0.814772, 'baz', ' '],
[-0.222552, ' ', 4],
[-1.176781, 'qux', ' '],
], columns='A B C'.split(), index=pd.date_range('2000-01-01','2000-01-06'))
# replace field that's entirely space (or empty) with NaN
print(df.replace(r'^\s*$',
…
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